Savlon Scar Prevention Gel 50g, First Aid Treatment to Help Soothe Minor Wounds and Burns and Reduce Likelihood of Scarring (Pack of 1, Packaging May Vary)

Product Information

A person can apply a thin layer of aloe vera gel to the wound area. They can also dress the wound in a bandage soaked in aloe vera gel to help with healing. Aids in chronic wounds, exudate absorbing capacity, optimizes moist microenvironment, and aids cell growth. In another study, a dual-responsive hydrogel against pH and ROS was designed to provide a dressing with sustained delivery of anti-inflammatory (nimesulide (NIM)) and antimicrobial (silver nanoclusters (VAN-AgNCs)) agents to the wound area [ 129]. This hydrogel was generated by crosslinking 3-carboxy-phenylboronic grafted gelatin with PVA. VAN-AgNCs was directly incorporated into the hydrogel while NIM was loaded in pH-sensitive micelles before being encapsulated into the hybrid hydrogels. Upon increased acidity or ROS levels in the wound environment, this hybrid hydrogel disintegrated and released the encapsulated VAN-AgNCs and micelles. The acidic environment further disintegrated the micelles to release NIM. VAN-AgNCs displayed effective antimicrobial activity while NIM exhibited an anti-inflammatory effect in both in vitro and in vivo experiments. In another study, a thermosensitive hybrid hydrogel was developed for the controlled release of MMP-9 siRNA to silence the MMP-9 gene [ 64]. MMP-9 is a matrix metalloproteinase displaying an important role in tissue remodeling. The excessive activation of MMP-9 causes degradation of local ECM which disrupts the cell migration and negatively affects the healing of diabetic wounds. Controlled release of MMP-9 siRNA from the thermosensitive hybrid hydrogels enabled down-regulation of the MMP-9 expression and improved the wound closure in a diabetic rat model.

He explained: “They merely prevent the wound from worsening and patients need to be scheduled for dressing change every two or three days. It is a huge cost to our healthcare system and an inconvenience to patients.”

Applied Sciences

Accelerated healing rate with promising epithelialization, angiogenesis, and less lipid peroxidation Currently, more than half a billion people globally are living with diabetes and this number is expected to rise significantly. Chronic diabetic wounds such as foot ulcers (one of the most common and hardest to treat wounds) have therefore become a major global healthcare challenge. Absorbing capacity, on shelf biomaterial, optimizes moist microenvironment, allows gas exchange, and cost effective. One 2016 review suggests that turmeric can be effective in helping wounds heal faster. It showed that the curcumin present in the spice stimulated the production of the growth factors involved in the healing process. It also showed that curcumin accelerated the management of wound restoration.

Hekmatpou, D., et al. (2019) . The effect of aloe vera clinical trials on prevention and healing of skin wound: A systematic review. Inflammatory cells, such as neutrophils, monocytes, and endothelial cells, adhere to a fibrin scaffold formed by platelet activation. The neutrophils enable phagocytosis of cellular debris and bacteria, allowing for decontamination of the wound. [4] The H&E stained skin section of day 24 showed an increase in epithelialization level (Fig. ​ (Fig.6a13-a16). 6a13-a16). Epithelialization score was found to be significantly increased in each treatment group compared to the control group. Among treated groups, AM+AV had a higher epithelialization ( P<0.05) rate than AV (Fig. ​ (Fig.6b). 6b). However, at this stage inflammation in AM+AV treated group increased again, while other treatment groups showed reduced inflammation (Fig. ​ (Fig.6c). 6c). At day 24, angiogenesis in the AV group ( P<0.05), was higher than in the AM and the AM+AV group (Fig. ​ (Fig.6d) 6d) but all groups showed elevated levels than the control. Wound healing is a natural physiological reaction to tissue injury. However, wound healing is not a simple phenomenon but involves a complex interplay between numerous cell types, cytokines, mediators, and the vascular system. The cascade of initial vasoconstriction of blood vessels and platelet aggregation is designed to stop bleeding. This is followed by an influx of a variety of inflammatory cells, starting with the neutrophil. These inflammatory cells, in turn, release a variety of mediators and cytokines to promote angiogenesis, thrombosis, and reepithelialization. The fibroblasts, in turn, lay down extracellular components which will serve as scaffolding. [1]This environment stimulates the release of several growth factors including but not limited to vascular endothelial growth factor (VEGF) and basic fibroblast factor (bFF). These growth factors help to drive neovascularisation and angiogenesis within the wound. Initial proliferative phase (poor blood supply) Prevents dehydration, optimizes moisture microenvironment, fills cavity wounds, ease of application and cost effective. Ansary, J., et al. (2020). Potential health benefit of garlic based on human intervention studies: A brief overview.

In total 40 healthy female Wistar rats of 180–200g body weight were used in this study and randomly assigned into four experimental groups (control/no gel, treated with AV, treated with AM and treated with AM+AV). All animals received human care according to the guideline for the care and use of laboratory animals published by NIH. Rats were fed a standard rat chow and tap water ad libitum. The rats were kept in the animal quarter at a temperature of 25±2°C, humidity 50–55% and with 14h light/10h dark cycles. Each rat was anesthetized with Ketamine HCl solution (Gonoshasthaya Pharmaceuticals Ltd., Bangladesh) of 100mg/Kg body weight by intra peritoneal injection. Subsequently, the hair at dorsal region was trimmed using electric hair clipper and then shaved with sharp blade. The shaved areas were cleansed with alcohol swab. Turmeric is a spice that comes from the plant of the same name. It contains curcumin, which has antibacterial, antifungal, and anti-inflammatory properties. Dextran hydrogel promoted rapid, efficient, and functional neovascularization without the addition of growth factors or cytokines In the pharmaceutical field, Col modified into nanospheres, nanoparticles or microspheres is used as a device for drug delivery in wound healing which may be formulated either through emulsification, desolvation, coacervation, spray drying, milling technique, fluidization, solvent precipitation method, extrusion, or interfacial polymerization [ 107]. In this form, they have been proven to be effective in penetrating into the systemic circulation with the aid of Col. This is made possible as the integration of Col has resulted in a larger wound surface area covered due to its small size, high absorption ability and capacity to form a colloidal solution [ 108]. Apart from this, the crystallite suspension in the gel aggregates emerges as a multiplex chain system in the Col fold configuration. This characteristic eases the formulation of aggregates into colloidal drug delivery carriers [ 109]. Meanwhile, the formation of nanospheres is regulated by a blend of different electronic and electrostatic forces, with sodium sulphate acting as the liquefying reagent to allow for maximum charge to charge linkages between DNA plasmid and Col, whereas for Col nanoparticles the molecular weight of the Col influences the stability of the Col nanoparticles [ 109]. Nonetheless, changes in pH and temperature have proven to have significant impact on the molecular weight of the collagen solution and the noncovalent linkage responsible for the collagen’s molecular structure during the formation of Col nanoparticles [ 110]. Proliferation is the third phase of wound healing. In this phase, granulated tissue with an extracellular matrix (ECM) composed of new connective tissue and blood vessels is formed in the presence of an appropriate amount of moisture and oxygen. The movement of T-lymphocytes (T-cells) into a wound bed plays an important role in granulated tissue formation. These T-cells secrete biomolecules, such as fibroblast growth factor 7 (FGF-7), keratinocyte growth factors (KGFs), and insulin-like growth factor-1 (IGF-1), to regulate fibroblast and keratinocyte expansion during this stage [ 6].The proliferative process is triggered by an environment of low wound pH, reduced PaO 2 and increased lactate (due to reduced blood supply to the wound). These results suggest that the gel and technology used by the researchers could be applied to healing other complex wounds, such as burns. Aloe vera is a plant belonging to the cactus family. It contains a substance that is rich in both vitamins and minerals. Heparinized human blood biocompatibility ( a), brine shrimp lethality bioassay (a6); HaCaT and HFF1 cells compatibility with gels ( b and c). RBC morphology of heparinized blood incubated with AM (a1), AV (a2), AM+AV (a3), DW (a4) and SW (a5). a6 diagram shows the mortality percentages of brine shrimp ( A. salina). 500μg/mL was shown to be suitable for HaCaT and HFF1 cells in vitro ( b and c) Methacrylate-modified chitosan (CS-GMA) and Arg-PEUU hybrid hydrogels exhibited an excellent antibacterial activity